Colleton County Vacations & Trips from $523

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Your Colleton County Vacation

Leave the planning up to us with a Colleton County vacation package. With everything arranged before you head off, the only thing left to do is sit back, chill out and experience this destination's culture and charm. Get your trip to Colleton County off to a great start by staying in its most famous cities. Walterboro is one you cannot miss. From the moment you book your Colleton County vacation to the second you come back home, Expedia will take care of you each step of the way.

Top destinations in Colleton County

The Latest Colleton County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Francis Marion Hotel
Emeline
Embassy Suites by Hilton Charleston Historic District
The Ryder Hotel
Hampton Inn Charleston-Historic District

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

Find the Best Colleton County Vacation Packages

Colleton County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Charleston Intl. Airport (CHS)

Colleton County Hotel Deals

Comfort Inn & Suites Walterboro I-95

Comfort Inn & Suites Walterboro I-95

2.5 out of 5
97 Downs Ln Walterboro SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Mar 8 to Mar 9
$113 total
Mar 8 - Mar 9
Total with taxes and fees
8.6/10 Excellent! (1,000 reviews)
Clean room, decent breakfast. The staff were friendly and helpful.

Reviewed on Feb 26, 2026

Comfort Inn & Suites Walterboro I-95
Microtel Inn & Suites by Wyndham Walterboro

Microtel Inn & Suites by Wyndham Walterboro

2 out of 5
130 Cane Branch Rd Walterboro SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Mar 4 to Mar 5
$106 total
Mar 4 - Mar 5
Total with taxes and fees
8/10 Very Good! (1,002 reviews)
Clean, the checking in & out was easy and fast. I like the breakfast selection.

Reviewed on Feb 26, 2026

Microtel Inn & Suites by Wyndham Walterboro
Baymont by Wyndham Walterboro

Baymont by Wyndham Walterboro

2.5 out of 5
1286 Sniders Hwy Walterboro SC
Fully refundableReserve now, pay when you stay
$50 nightly
The price is $56 total per night from Mar 2 to Mar 3
$56 total
Mar 2 - Mar 3
Total with taxes and fees
6.2/10 (1,062 reviews)
Room it was great and so was staff.... Very friendly unlike the hotel close to them, econo Lodge, weather managers are very rude and discriminate against people.

Reviewed on Feb 25, 2026

Baymont by Wyndham Walterboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.